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Sven N Hobbie Selected Research

apramycin

4/2024Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine blood stream infection models.
10/2022Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia.
10/2022Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
11/2021Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
9/2021Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland.
9/2021Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
8/2020Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV.
1/2020Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
1/2019In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.

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Sven N Hobbie Research Topics

Disease

12Infections
04/2024 - 03/2009
3Ototoxicity
01/2021 - 12/2008
2Bacterial Infections (Bacterial Infection)
08/2020 - 01/2020
1Bacteremia
04/2024
1Peritonitis
04/2024
1Gonorrhea
02/2024
1Pneumonia (Pneumonitis)
10/2022
1Pyelonephritis
11/2021
1Urinary Tract Infections (Urinary Tract Infection)
11/2021
1COVID-19
09/2021
1Superinfection
09/2021
1Bacterial Pneumonia
09/2021
1Sepsis (Septicemia)
01/2019
1Communicable Diseases (Infectious Diseases)
01/2019
1Influenza in Birds (Avian Flu)
04/2013
1Human Influenza (Influenza)
04/2013
1Parasitic Diseases (Parasitic Disease)
05/2011
1Hearing Loss (Hearing Impairment)
12/2008
1Deafness (Deaf Mutism)
12/2008
1Aminoglycoside-Induced Deafness
12/2008

Drug/Important Bio-Agent (IBA)

11AminoglycosidesIBA
04/2024 - 12/2008
9apramycinIBA
04/2024 - 01/2019
9Anti-Bacterial Agents (Antibiotics)IBA
01/2022 - 05/2011
4Carbapenems (Carbapenem Antibiotics)IBA
04/2024 - 08/2020
3Amikacin (A.M.K)FDA LinkGeneric
01/2022 - 09/2021
2Gentamicins (Gentamicin)FDA LinkGeneric
02/2024 - 11/2021
2propylamycinIBA
01/2021 - 01/2019
2Paromomycin (Paromomycin Sulfate)FDA LinkGeneric
01/2019 - 05/2011
1gentamicin CIBA
02/2024
1etimicinIBA
02/2024
1Netilmicin (Netromycin)FDA Link
02/2024
1AminesIBA
11/2021
1IsoenzymesIBA
01/2021
1TransferasesIBA
01/2019
1EnzymesIBA
01/2019
1Polysaccharides (Glycans)IBA
04/2013
1StreptavidinIBA
04/2013
1Hemagglutinins (Hemagglutinin)IBA
04/2013
1Indicators and Reagents (Reagents)IBA
04/2013
1Ribosomal Protein L3IBA
03/2009
123S Ribosomal RNAIBA
03/2009
1tiamulinIBA
03/2009
1Proteins (Proteins, Gene)FDA Link
12/2008
1Mitochondrial Proteins (Mitochondrial Protein)IBA
12/2008

Therapy/Procedure

4Therapeutics
01/2022 - 08/2020
1Mechanical Ventilators (Ventilator)
09/2021
1Microspheres (Microsphere)
04/2013